A Systematic Approach to Identify Markers of Distinctly Activated Human Macrophages

ABSTRACT: Polarization has been a useful concept for describing activated macrophage phenotypes and gene expression profiles. However, macrophage activation status within tumors and other settings are often inferred based on only a few markers. Complicating matters for relevance to human biology, many of the best studied macrophage activation markers have been best characterized in mice and sometimes are not similarly regulated in human macrophages. To identify novel markers of activated human macrophages, gene expression profiles for human macrophages of a single donor subjected to 33 distinct activating conditions were obtained and a set of putative activation markers were subsequently evaluated in macrophages from multiple donors using integrated fluidic circuit (IFC)-based RT-PCR. Using unsu

ORGANISM(S): Homo sapiens

SUBMITTER: Joel Graff 

PROVIDER: E-GEOD-68854 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress