Transcription profiling of human keratinocytes used in a small molecule screen to identify inducers of epidermal keratinocyte differentiation

ABSTRACT: An essential function of the human epidermis is the maintenance of a protective barrier against the environment. As a consequence, keratinocytes, which make up this layer of the skin, undergo an elaborate process of self-renewal, terminal differentiation and cell death. Misregulation of these processes can lead to several human diseases including psoriasis and basal cell and squamous cell carcinomas. To identify novel regulators of keratinocyte differentiation, a cell-based screen of small molecule libraries was carried out for molecules that induce terminal differentiation of normal human epidermal keratinocytes (NHEKs). One class of molecules was identified, the 2-(3,4,5-trimethoxy-phenylamino)-pyrrolo[2,3-d]pyrimidines, which were shown to induce differentiation of epidermal progenitor

ORGANISM(S): Homo sapiens

SUBMITTER: John Walker 

PROVIDER: E-GEOD-6932 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress