The microRNA signature of mouse spermatozoa is dynamically modified during epididymal maturation

ABSTRACT: In recent years considerable effort has been devoted to understanding the epigenetic control of sperm development leading to an increased appreciation of the importance of RNA interference pathways, and in particular microRNAs (miRNAs), as key regulators of spermatogenesis and epididymal maturation. It has also been shown that sperm are endowed with an impressive array of miRNA that have been implicated in various aspects of fertilization and embryo development. However, to date there have been no reports on whether the sperm miRNA signature is static or whether it is influenced by their prolonged maturation within the male reproductive tract. To investigate this phenomenon we employed next generation sequencing to systematically profile the miRNA signature of maturing mouse spermatozoa. I

ORGANISM(S): Mus musculus

SUBMITTER: Brett Nixon 

PROVIDER: E-GEOD-70198 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress