The relationship between gene network structure and expression variation among individuals and species

ABSTRACT: Variation among individuals is a prerequisite of evolution by natural selection. As such, identifying the origins of variation is a fundamental goal of biology. We investigated the link between gene interactions and variation in gene expression among individuals and species, using the mammalian limb as a model system. We first built interaction networks for key genes regulating early (outgrowth; E9.5-11) and late (expansion and elongation; E11-13) limb development in mouse. This resulted in an Early (ESN) and Late (LSN) Stage Network. Computational perturbations of these networks suggest that the ESN is more robust. We then quantified levels of the same key genes among mouse individuals, and found that they vary less at earlier limb stages and that variation in gene expression is heritable

ORGANISM(S): Sus scrofa

SUBMITTER: Marcelo Rivas 

PROVIDER: E-GEOD-71390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress