RNA-Sequencing shows novel transcriptomic signatures in failing and non-failing human heart

ABSTRACT: The knowledge of an expression network signature in end-stage heart failure (HF) diseased hearts may offer important insights into the complex pathogenesis of advanced cardiac failure, as well as it may provide potential targets for therapeutic intervention. In this study, the NGS sequencing of RNA (RNA-Seq) method was employed to obtain the whole transcriptome of cardiac tissues from transplant recipients with advanced stage of HF. The analysis of RNA-Seq data presents novel challenges and many methods have been developed for the purpose of mapping reads to genomic features and quantifying gene expression. The main goal of this work was to identify, characterize and catalogue all the transcripts expressed within cardiac tissue and to quantify the differential expression of transcripts in

ORGANISM(S): Homo sapiens

SUBMITTER: Valerio Costa 

PROVIDER: E-GEOD-71613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress