Dynamic membrane depolarization is an early regulator of ependymoglial cell response to spinal cord injury in axolotl

ABSTRACT: Salamanders, such as the Mexican axolotl, are some of the few vertebrates fortunate in their ability to regenerate diverse structures after injury. Unlike mammals they are able to regenerate a fully functional spinal cord after injury. However, the early signals required to initiate a pro-regenerative response after spinal cord injury is not well understood. To address this question we developed a spinal cord injury model in axolotls and used in vivo imaging of ion sensitive dyes and determined that spinal cord injury induces a rapid and dynamic change in the resting membrane potential of ependymoglial cells. Prolonged depolarization of ependymoglial cells after injury inhibits glial cell proliferation and subsequent axon regeneration. Using transcriptional profiling we identified c-Fos as

ORGANISM(S): Ambystoma mexicanum

SUBMITTER: Karen Echeverri 

PROVIDER: E-GEOD-71934 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress