Microarray data for Rheumatoid arthritis synovial fibroblast (RASF) after C5orf30 and HDAC1 knockdown

ABSTRACT: The variant rs26232, in the first intron of the C5orf30 locus, has recently been associated with both risk of developing rheumatoid arthritis (RA) and severity of tissue damage. The biological activities of human C5orf30 are unknown, and neither the gene nor protein show significant homology to any other characterized human sequences. The C5orf30 gene is present only in vertebrate genomes with a high degree of conservation implying a central function in these organisms. Here we report that C5orf30 is highly expressed in the synovium of RA patients compared with control synovial tissue, and that it is predominately expressed by synovial fibroblast (RASF) and macrophages in the lining and sublining layer of the tissue. These cells play a central role in the initiation and perpetuation of RA

ORGANISM(S): Homo sapiens

SUBMITTER: Munitta Muthana 

PROVIDER: E-GEOD-72258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress