SOX9 modulates the expression of key transcription factors required for heart valve development

ABSTRACT: Heart valve formation initiates when endothelial cells of the heart transform into mesenchyme and populate the cardiac cushions. The transcription factor, SOX9, is highly expressed in the cardiac cushion mesenchyme, and is essential for heart valve development. Loss of Sox9 in mouse cardiac cushion mesenchyme alters cell proliferation, embryonic survival, and disrupts valve formation. Despite this important role, little is known regarding how SOX9 regulates heart valve formation or its transcriptional targets. Therefore, we mapped putative SOX9 binding sites by ChIP-Seq in embryonic day (E) 12.5 heart valves, a stage at which the valve mesenchyme is actively proliferating and initiating differentiation. Embryonic heart valves have been shown to express a high number of genes that are assoc

ORGANISM(S): Mus musculus

SUBMITTER: Pamela Hoodless 

PROVIDER: E-GEOD-73225 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress