The genomic responses of mouse liver to diclofenac treatment reveals an immune mediated mechanism of liver injury

ABSTRACT: Diclofenac (DCL) is a non-steroidal anti-inflammatory drug. Its use can be associated with serious adverse drug reactions most notable myocardial infarction and drug-induced liver injury (DILI). The molecular causes leading to DILI remains unclear and it seems to be multifactorial. The aims of this study is to identify the molecular mechanisms involving immune mediated inflammatory reactions and its link to DILI through whole genome gene expression profiling. Diclofenac was given to mice at 30 mg/kg for 1, 3 and 14 days. Microarray experiments were performed with RNA extracts from liver samples. The performed gene expression studies showed >600 significantly regulated genes after single and repeated dosing for 3 and 14 days. The functional annotation revealed several genes were regulated i

ORGANISM(S): Mus musculus

SUBMITTER: Jürgen Borlak 

PROVIDER: E-GEOD-75277 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress