5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats

ABSTRACT: Though obesity is a global epidemic, the physiological mechanisms involved are little understood. Recent advances reveal that susceptibility to obesity can be programmed by maternal and neonatal nutrition. Specifically, a maternal low protein diet during pregnancy causes decreased intrauterine growth, rapid postnatal catch-up growth and increased risk for diet-induced obesity. Given that the synthesis of the neurotransmitter 5-hydroxytryptamine (5-HT) is nutritionally regulated and 5-HT is a trophic factor, we hypothesized that maternal diet influences fetal 5-HT exposure, which then influences central appetite network development and the subsequent efficacy of 5-HT to control energy balance in later life. Consistent with our hypothesis, pregnant low protein fed rat mothers exhibited eleva

ORGANISM(S): Rattus norvegicus

SUBMITTER: Brian Lam 

PROVIDER: E-GEOD-76012 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress