Halobacterium NRC-1, NiSO4 Stress Response series 2

ABSTRACT: Given that transition metals are essential cofactors in central biological processes, misallocation of the wrong metal ion to a metalloprotein can have resounding and often detrimental effects on diverse aspects of cellular physiology. Therefore, in an attempt to characterize unique and shared responses to chemically similar metals we have reconstructed physiological behaviors of Halobacterium NRC-1, an archaeal halophile, in sub-lethal levels of Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II). Over 20% of all genes responded transiently within minutes of exposure to Fe(II), perhaps reflecting immediate large scale physiological adjustments to maintain homeostasis. At steady state, each transition metal induced growth arrest, attempts to minimize oxidative stress, toxic ion scavenging, i

ORGANISM(S): Halobacterium sp. NRC-1

SUBMITTER: Raffat El-Geweley 

PROVIDER: E-GEOD-7613 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress