Autonomous extracellular matrix remodeling controls a progressive adaptation in muscle stem cell regenerative capacity during development

ABSTRACT: Muscle stem cells (MuSC) exhibit distinct behaviors during successive phases of developmental myogenesis. However, how their transition to adulthood is regulated is poorly understood. Here we show that fetal MuSC resist progenitor specification and exhibit altered division dynamics, intrinsic features that are progressively lost postnatally. Following transplantation, fetal MuSC more efficiently expand and contribute to muscle repair. Conversely, the efficiency of niche colonization increases in adulthood, indicating a balance between muscle growth and stem cell pool repopulation. Gene expression profiling identified several extracellular matrix (ECM) molecules preferentially expressed in fetal MuSC, including tenascin-C, fibronectin and collagen VI. Loss-of-function experiments confirmed

ORGANISM(S): Mus musculus

SUBMITTER: Francesca Boscolo 

PROVIDER: E-GEOD-76989 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress