Transcription profiling of mouse skeletal muscle of integrin alpha7 overexpressing animals vs controlls

ABSTRACT: Analysis of integrin alpha7 transgenic mice skeletal muscle transcription profiles comparing to wild type controls. Integrin alpha7 is the major laminin binding integrin in muscle cells. Enhancing its expression has been demonstrated to alleviate pathology in a murine model of Duchenne muscular dystrophy. Results of this study provide insights into the effects of increasing integrin alpha7 expression on skeletal muscle transcription and physiology in vivo. This analysis also evaluates any potential possible side effects associate with enhancing integrin alpha7 in skeletal muscle. Experiment Overall Design: Equal amount of total RNA from six animals of each genotype were pooled to generate a biological replicate. Total of three biological replicates were used. Together, 18 mice of each gen

ORGANISM(S): Mus musculus

SUBMITTER: Jianming Liu 

PROVIDER: E-GEOD-8313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress