Global methylation analysis of development and progression of colorectal carcinoma

ABSTRACT: Colorectal tumorigenesis proceedes through well defined clinical stages assoicated with charateristic mutations. Besides genetic alterations, epi-driver genes that are aberrantly expressed in cancers in a fashion that confers a seletive growth advantage can also contribute to tumor evolution. To gain a global view of methylation patterns in normal and maliganant colorectal epithelia, we performed genome-wide DNA methylation analysis on DNAs from 48 fresh frozen CRC samples at different stages of CRC progression. We used IlluminaHumanMethylation450 Beadchip to get a broad view of genome-wide DNA methylationdata during CRC progression and identified significantly differentially methylated genes during CRC progression A total of 48 macro-dissected tissues including normal colon tissue, ade

ORGANISM(S): Homo sapiens

SUBMITTER: Omar Kabbarah 

PROVIDER: E-GEOD-77954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress