Integrative functional genomic analysis identifies epigenetically regulated Fibromodulin as an essential gene for glioma cell migration

ABSTRACT: An integrative functional genomics of multiple forms of data is vital for discovering molecular drivers of cancer development and progression. Here, we present an integrated genomic strategy utilizing DNA methylation and transcriptome profile data to discover epigenetically regulated genes implicated in cancer development and invasive progression. More specifically, this analysis identified Fibromodulin (FMOD) as a glioblastoma (GBM) upregulated gene due to the loss of promoter methylation. Secreted FMOD promotes glioma cell migration through its ability to induce filamentous actin stress fiber formation. Treatment with Cytochalasin D, an actin polymerization inhibitor, significantly reduced the FMOD induced glioma cell migration. siRNA and small molecule inhibitor-based studies identified

ORGANISM(S): Homo sapiens

SUBMITTER: Vikas Patil 

PROVIDER: E-GEOD-79122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress