Transcription profiling of human VEGF-derived CD8+ T-cell epitope

ABSTRACT: The vascular endothelial growth factor A (VEGF) is involved in various physiological processes such as angiogenesis or wound healing but is also crucial in pathological events such as tumor growth. Thus, clinical anti-VEGF treatments have been developed which could already prove to have enormous beneficial effects for cancer patients. In this article we describe the first VEGF-derived CD8+ T-cell epitope. The natural HLA ligand SRFGGAVVR was identified by differential mass spectrometry in two primary renal cell carcinomas (RCC) and was significantly over-presented on both tumor tissues. SRFGGAVVR is derived from a cryptic translated region of VEGF presumably by initiation of translation at the non-classical start codon CUG499. SRFGGAVVR specific T-cells were generated in vitro using peptid

ORGANISM(S): Homo sapiens

SUBMITTER: Andreas Oliver Weinzierl 

PROVIDER: E-GEOD-8050 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress