Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Victoria Cowling
PROVIDER: E-GEOD-81849 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Grasso Laura L Suska Olga O Davidson Lindsay L Gonatopoulos-Pournatzis Thomas T Williamson Ritchie R Wasmus Lize L Wiedlich Simone S Peggie Mark M Stavridis Marios P MP Cowling Victoria H VH
Cell reports 20160721 5
The mRNA cap recruits factors essential for transcript processing and translation initiation. We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation. Expression of the mRNA cap methyltransferase activating subunit RAM is elevated in ESCs, resulting in high levels of mRNA cap methylation and expression of a cohort of pluripotency-associated genes. During neural differentiation, RAM is suppressed, resulting in repression of pluripotency-associated f ...[more]