The antimicrobial peptide-sensing system aps of Staphylococcus aureus

ABSTRACT: Staphylococcus aureus is a leading cause of hospital-associated infections. In addition, highly virulent strains of methicillin-resistant S. aureus (MRSA) are currently spreading outside health care settings. Survival in the human host is largely defined by the ability of S. aureus to resist mechanisms of innate host defense, of which antimicrobial peptides form a key part especially on epithelia and in neutrophil phagosomes. Here we demonstrate that the antimicrobial-peptide sensing system aps of the standard community-associated MRSA strain MW2 controls resistance to cationic antimicrobial peptides. The core of aps-controlled resistance mechanisms comprised the D-alanylation of teichoic acids (dlt operon), the incorporation of cationic lysyl-phosphatidylglycerol (L-PG) in the bacterial m

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Dan Sturdevant 

PROVIDER: E-GEOD-8400 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress