Transcription profiling of Drosophila embryo - comparison of Dorsal threshold outputs

ABSTRACT: Whole-Genome Analysis of Dorsal-Ventral Patterning in the Drosophila Embryo. The maternal Dorsal regulatory gradient initiates the differentiation of several tissues in the early Drosophila embryo. Whole-genome microarray assays identified as many as 40 new Dorsal target genes, which encode a broad spectrum of cell signaling proteins and transcription factors. Evidence is presented that a tissue-specific form of the NF-Y transcription complex is essential for the activation of gene expression in the mesoderm. Tissue-specific enhancers were identified for new Dorsal target genes, and bioinformatics methods identified conserved cis-regulatory elements for coordinately regulated genes that respond to similar thresholds of the Dorsal gradient. The new Dorsal target genes and enhancers represen

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Angelike Stathopoulos 

PROVIDER: E-GEOD-86 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress