Transcription profiling of mouse macrophages exposed to LPS

ABSTRACT: Among the multiple mechanisms that control the intensity and duration of macrophage activation, the development of a state of refractoriness to a second stimulation in cells treated with LPS has long been recognized. Release of inhibitory cytokines and alterations in intracellular signaling pathways may be involved in the development of LPS tolerance. Although a number of molecules have been implicated, a detailed picture of the molecular changes in LPS tolerance is still missing. We have used a genome-wide gene expression analysis approach to (i) define which fraction of LPS target genes are subject to tolerance induction and (ii) identify genes that are expressed at high levels in tolerant macrophages. Our data show that in LPS tolerant macrophages the vast majority of LPS-induced gene e

ORGANISM(S): Mus musculus

SUBMITTER: Joerg Mages 

PROVIDER: E-GEOD-8621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress