Transcription profiling of S. cerevisiae treated with phenelzine results in a perturbation in the system leads to period doubling

ABSTRACT: Perturbation of the gated-synchrony system in yeast with phenelzine, an antidepressant drug used in the treatment of affective disorders in humans, leads to a rapid lengthening in the period of the genome-wide transcriptional oscillation. The effect is a concerted, genome-scale change in expression that is first seen in genes maximally expressed in the late-reductive phase of the cycle, doubling the length of the reductive phase within two cycles after treatment. Clustering of genes based on their temporal patterns of expression yielded just three super clusters whose trajectories through time could then be mapped into a simple 3D figure. In contrast to transcripts in the late-reductive phase, most transcripts do not show transients in expression relative to others in their temporal cluste

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Robert Klevecz 

PROVIDER: E-GEOD-9302 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress