Conserved tissue expression signatures of intronic noncoding RNAs transcribed from human and mouse loci

ABSTRACT: It has been postulated that noncoding RNAs (ncRNAs) are involved in the post-transcriptional control of gene expression, and may have contributed to the emergence of the complex attributes observed in mammalians. The complement of ncRNAs expressed from intronic regions of the human and mouse genomes comprises at least 78,147 and 39,660 transcriptional units, respectively. To identify conserved intronic sequences expressed in both humans and mice, we used custom-designed human cDNA microarrays to separately interrogate RNA from mouse and human liver, kidney and prostate tissues. An overlapping tissue expression signature was detected for both species, comprising 198 transcripts; among these, twenty two RNAs map to intronic regions with evidence of evolutionary conservation in humans and mic

ORGANISM(S): Mus musculus

SUBMITTER: Rodrigo Louro 

PROVIDER: E-GEOD-9950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress