Transcription profiling of rat hippocampus and cortex in the time series of Pneumococcal Meningitis infection

ABSTRACT: The aim of this work is to describe the transcriptomic changes underlying the complex mechanisms of the host response to pneumococcal meningitis in a temporal and spatial context. For this purpose we evaluated the gene expression profile of the two brain structures predominantly affected by brain damage i.e. the cortex and the hippocampus at four different stages of the disease (24-, 72-, 240- and 624 hours post infection) using an infant rat model.

The first two timepoints represent the acute and late disease phase of bacterial meningitis (BM) and 10 and 26days the recovery phase. At each timepoint 6 infected and 6 sham infected animals were sacrificed. Control and infected animals were age matched to avoid differences in the gene expression patterns due to developmental processes

ORGANISM(S): Rattus norvegicus

SUBMITTER: Matthias Wittwer 

PROVIDER: E-MEXP-1656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress