Transcription profiling of mesenchymal stem cells exposed to CM from tumor cells or bone marrow
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Mythili Koneru
PROVIDER: E-MEXP-532 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential gene expression associated with migration of mesenchymal stem cells to conditioned medium from tumor cells or bone marrow cells.
Menon Lata G LG Picinich Sonia S Koneru Rajeth R Gao Hui H Lin Siang Yo SY Koneru Mythili M Mayer-Kuckuk Philipp P Glod John J Banerjee Debabrata D
Stem cells (Dayton, Ohio) 20061019 2
Distinct signals that guide migration of mesenchymal stem cells (MSCs) to specific in vivo targets remain unknown. We have used rat MSCs to investigate the molecular mechanisms involved in such migration. Rat MSCs were shown to migrate to tumor microenvironment in vivo, and an in vitro migration assay was used under defined conditions to permit further mechanistic investigations. We hypothesized that distinct molecular signals are involved in the homing of MSCs to tumor sites and bone marrow. To ...[more]
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