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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human embryonic stem cells and their differentiated progeny grown in chemically defined conditions

ABSTRACT: Comparison of H9 human embryonic stem cells, grown in chemically defined and animal-product free conditions, with their differentiated progeny - mesendodermal progenitors arisen as the result of changes made to chemically defined hESC growth conditions. Contributes to a larger work on the use of chemically defined growth conditions to direct hESC differentiation.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthew Trotter

PROVIDER: E-MEXP-930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early cell fate decisions of human embryonic stem cells and mouse epiblast stem cells are controlled by the same signalling pathways.

Vallier Ludovic L Touboul Thomas T Chng Zhenzhi Z Brimpari Minodora M Hannan Nicholas N Millan Enrique E Smithers Lucy E LE Trotter Matthew M Rugg-Gunn Peter P Weber Anne A Pedersen Roger A RA

PloS one 20090630 6

Human embryonic stem cells have unique value for regenerative medicine, as they are capable of differentiating into a broad variety of cell types. Therefore, defining the signalling pathways that control early cell fate decisions of pluripotent stem cells represents a major task. Moreover, modelling the early steps of embryonic development in vitro may provide the best approach to produce cell types with native properties. Here, we analysed the function of key developmental growth factors such a ...[more]

PMID: 19564924

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