MiR-143-5p suppresses breast cancer progression by targeting the HIF-1α-related GLUT1 pathway

ABSTRACT: Breast cancer (BC) is a commonly identified life-threatening type of cancer and a major cause of death among women worldwide. Several microRNAs (miRs), including miR-143-5p, have been reported to be vital for regulating hallmarks of cancer; however, the effect of miR-143-5p on BC requires further exploration. The present study performed bioinformatics analysis on GSE42072 and GSE41922 datasets from the National Center for Biotechnology Information Gene Expression Omnibus (GEO) database to identify miR-143-5p expression patterns. Furthermore, miR-143-5p expression was detected in BC cell lines and tissues via reverse transcription-quantitative PCR. Post-transfection with miR-143-5p mimics, Cell Counting Kit-8, colony formation and Transwell assays were performed to explore the effects of mi

ORGANISM(S): Homo sapiens

SUBMITTER: Shiwei Liu 

PROVIDER: E-MTAB-11160 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress