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A cell atlas of the human outflow tract of the heart and its adult derivatives - Adult samples

ABSTRACT: Congenital heart disease (CHD) is a major birth defect affecting ~1% of new born babies. The OFT carries blood away from the heart into the great arteries. Defects specifically affecting the outflow tract (OFT) of the heart represent a third of all CHD cases. In humans the formation and remodelling of the OFT is a relatively rapid process, occurring over a 3-week period (Carnegie Stage (CS)13 – CS22). The morphological changes underlying OFT formation are orchestrated by two main cell lineages, second heart field (SHF)-derived myocardium and endothelium, and neural crest cells (NCC). Here, we present comprehensive transcriptomic data on the developing OFT at two distinct timepoint (embryonic and fetal) and its adult derivatives, providing a large reference framework of OFT cell repertoires and their gene expression profiles. This submission has the Adult dataset of this work.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Syed Murtuza Baker

PROVIDER: E-MTAB-13453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A cell atlas of the human outflow tract of the heart and its adult derivatives

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