Transcriptional profile assessed by microarrays of the tidepool sculpin and silverspotted sculpin exposed to hypoxia over time

ABSTRACT: Transcriptional responses to hypoxia were compared between a hypoxia tolerant fish (tidepool sculpin; Oligocottus maculosus) and a hypoxia intolerant fish (silverspotted sculpin; Blepsias cirrhosus). To determine if, and how, transcriptional plasticity is associated with differences in hypoxia tolerance, each species was subjected to a hypoxic time-course and liver was sampled at normoxia, 3hr, 8hr, 24hr, 48hr and 72hr of hypoxia. The hypoxic level for each species was scaled to the species' own tolerance level (relative exposure) in order to elicit similar tissue level hypoxia between the two sculpin species. Each species was also subjected to a single environmental O2 tension (absolute exposure) and sampled at 24 hrs of hypoxia.

ORGANISM(S): Oligocottus maculosus

SUBMITTER: Milica Mandic 

PROVIDER: E-MTAB-3043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress