Transcription profiling by array of mouse dendritic cells stimulated with live influenza virus, influenza whole inactivated virus vaccine or subunit vaccine.

ABSTRACT: Vaccine development involves time-consuming and expensive evaluation of candidate vaccines in animal models. As mediators of both innate and adaptive immune responses dendritic cells (DCs) are considered to be highly important for vaccine performance. Here we evaluated in how far the response of DCs to a vaccine in vitro is in line with the immune response the vaccine evokes in vivo. To this end, we investigated the response of murine bone marrow-derived DCs to whole inactivated virus (WIV) and subunit (SU) influenza vaccine preparations. These vaccine preparations were chosen because they differ in the immune response they evoke in mice with WIV being superior to SU vaccine through induction of higher virus-neutralizing antibody titers and a more favorable Th1-skewed response phenotype. T

ORGANISM(S): Mus musculus

SUBMITTER: Maaike Stoel 

PROVIDER: E-MTAB-3115 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress