Global gene expression response in peripheral blood cells of petroleum workers exposed to very low benzene levels

ABSTRACT: Benzene, a natural component of petroleum products, is a known hematotoxic and leukemogenic agent. The haematotoxic effect and excess leukemia has been reported below 1 ppm, an exposure level previously considered not to cause any health effects. Gene expression studies suggest that benzene affects genes involved in AML and immune response pathways in a supra-linear manner, and at exposure levels as low as 0.1 ppm benzene. An increased risk of haematopoietic malignancies and altered gene expression also at exposure below 1 ppm is compatible with the emerging knowledge of a non-linear metabolism of benzene, favouring production of a greater proportion of toxic metabolites in subjects exposed to benzene concentrations below 1 ppm than in heavily exposed workers. In the present study, we inve

INSTRUMENT(S): Illumina BeadScan

ORGANISM(S): Homo sapiens

SUBMITTER: Jorunn Kirkeleit 

PROVIDER: E-MTAB-5331 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress