Dataset Information


Gene expression in benzene-exposed workers

ABSTRACT: The effect of benzene exposure on peripheral blood mononuclear cell (PBMC) gene expression was examined in a population of shoe-factory workers with well-characterized occupational exposures to benzene. We compared data from two microarray platforms (Illumina and Affymetrix). Keywords: occupational exposure Overall design: Eight workers exposed to benzene and eight unexposed controls who were frequency-matched to these subjects on the basis of age and gender were analyzed. Affymetrix and Illumina arrays. Illumina: Group A - control, Group B - benzene.

INSTRUMENT(S): [HG-U133A] Affymetrix Human Genome U133A Array

SUBMITTER: Cliona McHale  

PROVIDER: GSE9569 | GEO | 2009-05-11



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Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms.

McHale Cliona M CM   Zhang Luoping L   Lan Qing Q   Li Guilan G   Hubbard Alan E AE   Forrest Matthew S MS   Vermeulen Roel R   Chen Jinsong J   Shen Min M   Rappaport Stephen M SM   Yin Songnian S   Smith Martyn T MT   Rothman Nathaniel N  

Genomics 20090120 4

Benzene is an established cause of leukemia, and possibly lymphoma, in humans, but the underlying molecular pathways remain largely undetermined. We used two microarray platforms to identify global gene expression changes associated with well-characterized occupational benzene exposure in the peripheral blood mononuclear cells (PBMC) of a population of shoe-factory workers. Differential expression of 2692 genes (Affymetrix) and 1828 genes (Illumina) was found and the concordance was 50% (based o  ...[more]

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