Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analyses of the response of C. glabrata wild type cells to iron excess, salt excess, cadmium treatment and iron starvation

ABSTRACT: A Candida glabrata wild type strain (HTL, as described in Schwartzmuller et al., PLoS Pathog. 2014 Jun 19;10(6):e1004211) was submitted to various stress conditions (iron excess, salt excess, cadmium treatment and iron starvation (BPS treatment). The cells were collected 20 and 40 minutes after the beginning of treatments and their transcriptomes were compared to those of mock treated cells.

ORGANISM(S): [Candida] glabrata

SUBMITTER: Frederic Devaux 

PROVIDER: E-MTAB-7043 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Comparative Transcriptomics Highlights New Features of the Iron Starvation Response in the Human Pathogen <i>Candida glabrata</i>.

Benchouaia Médine M   Ripoche Hugues H   Sissoko Mariam M   Thiébaut Antonin A   Merhej Jawad J   Delaveau Thierry T   Fasseu Laure L   Benaissa Sabrina S   Lorieux Geneviève G   Jourdren Laurent L   Le Crom Stéphane S   Lelandais Gaëlle G   Corel Eduardo E   Devaux Frédéric F  

Frontiers in microbiology 20181116

In this work, we used comparative transcriptomics to identify regulatory outliers (ROs) in the human pathogen <i>Candida glabrata</i>. ROs are genes that have very different expression patterns compared to their orthologs in other species. From comparative transcriptome analyses of the response of eight yeast species to toxic doses of selenite, a pleiotropic stress inducer, we identified 38 ROs in <i>C. glabrata</i>. Using transcriptome analyses of <i>C. glabrata</i> response to five different s  ...[more]

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