Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Neurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency

ABSTRACT: Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair, and survival of neurons; playing a role in the maintenance of the synaptic unions, dendrites and axons; also, being crucial for peripheral nervous system development and regulating plasticity in the adult central nervous system. On the other hand, insulin-like growth factor 1 (IGF-1) has been ascertained multiple beneficial actions in the brain: neuro-development, -protection, -genesis and plasticity. To further investigate the possible mechanisms underlying IGF-1 deficiency in the establishment of neurological disease, microarray and RT-qPCR gene expression analyses coupled with in silico processing were performed in an experimental model of partial IGF-1 deficiency. Results show that the mere IGF-1 deficiency seems to be responsible for an altered expression of genes coding for neurotrophic factors (particularly ciliary neurotrophic factor and mesencephalic astrocyte-derived neurotrophic factor), their receptors and signaling pathways (specially RET). The presented findings support that IGF-1 deficiency might be involved in the establishment and progression of neurodegenerative disorders.

ORGANISM(S): Mus musculus

SUBMITTER: Irene Martin-Estal

PROVIDER: E-MTAB-7508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy.

Puche Juan E JE Muñoz Úrsula Ú García-Magariño Mariano M Sádaba María C MC Castilla-Cortázar Inma I

BioFactors (Oxford, England) 20160101 1

Insulin-like growth factor 1 (IGF-1) induces multiple cytoprotective effects on every tissue, including the brain. Since the mechanisms by which IGF-1 produces neuroprotection are not fully understood, the aim of this work was to delve into the underlying mechanisms. IGF-1 deficient mice (Hz) were compared with wild type (WT) and Hz mice treated with low doses of IGF-1 (2 µg/100 g body weight/day) for 10 days (Hz + IGF). Gene expression, quantitative PCR, histology, and magnetic resonance imagin ...[more]

PMID: 26891019

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Dataset Information

Neurotrophic factors and their receptors are altered by the mere partial IGF-1 deficiency

Publications

Partial IGF-1 deficiency induces brain oxidative damage and edema, which are ameliorated by replacement therapy.

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