Transcription profiling of C. elegans wild type L2 or L3 larvae (non-dauer) vs TGFbeta mutants at similar developmental stages undergoing dauer formation

ABSTRACT: BACKGROUND: When resources are scant, C. elegans larvae arrest as long-lived dauers under the control of insulin/IGF- and TGFbeta-related signaling pathways. RESULTS: We have identified genes that show different levels of expression in a comparison of wild-type L2 or L3 larvae (non-dauer) to TGFbeta mutants at similar developmental stages undergoing dauer formation. Many insulin/IGF pathway and other known dauer regulatory genes have changes in expression that suggest strong positive feedback by the TGFbeta pathway. In addition, many insulin-like ligand and novel genes with similarity to the extracellular domain of insulin/IGF receptors have altered expression. We have identified a large group of regulated genes with putative binding sites for the FOXO transcription factor, DAF-16. Genes w

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-3596 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress