Transcription profiling of neurosphere-derived cell lines from patients with brain disorders

ABSTRACT: Understanding the molecular bases of neurological and psychiatric conditions is hampered by a lack of suitable patient-derived cellular models. The olfactory mucosa is a continually regenerating neural tissue that contains multipotent neural stem cells which are accessible and expandable in vitro as neurospheres. Here we demonstrate disease-specific differences in neurosphere-derived cell lines from patients with two unrelated neurological conditions. Lines derived from donors with schizophrenia exhibited significant dysregulation of neurodevelopmental pathways whereas those obtained from donors with Parkinson's disease demonstrated significant dysgregulation in mitochondrial function, oxidative stress and xenobiotic metabolism. Our model supports the hypothesis that diseases with multiple

ORGANISM(S): Homo sapiens

DISEASE(S): Parkinson's disease

SUBMITTER: Nicholas Matigian 

PROVIDER: E-TABM-724 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress