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ZnO Tetrapods for Label-Free Optical Biosensing: Physicochemical Characterization and Functionalization Strategies.

ABSTRACT: In this study, we fabricated three different ZnO tetrapodal nanostructures (ZnO-Ts) by a combustion process and studied their physicochemical properties by different techniques to evaluate their potentiality for label-free biosensing purposes. Then, we explored the chemical reactivity of ZnO-Ts by quantifying the available functional hydroxyl groups (-OH) on the transducer surface necessary for biosensor development. The best ZnO-T sample was chemically modified and bioconjugated with biotin as a model bioprobe by a multi-step procedure based on silanization and carbodiimide chemistry. The results demonstrated that the ZnO-Ts could be easily and efficiently biomodified, and sensing experiments based on the streptavidin target detection confirmed these structures' suitability for biosensing applications.

SUBMITTER: Terracciano M 

PROVIDER: S-EPMC10002590 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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ZnO Tetrapods for Label-Free Optical Biosensing: Physicochemical Characterization and Functionalization Strategies.

Terracciano Monica M   Račkauskas Simas S   Falanga Andrea Patrizia AP   Martino Sara S   Chianese Giovanna G   Greco Francesca F   Piccialli Gennaro G   Viscardi Guido G   De Stefano Luca L   Oliviero Giorgia G   Borbone Nicola N   Rea Ilaria I  

International journal of molecular sciences 20230223 5

In this study, we fabricated three different ZnO tetrapodal nanostructures (ZnO-Ts) by a combustion process and studied their physicochemical properties by different techniques to evaluate their potentiality for label-free biosensing purposes. Then, we explored the chemical reactivity of ZnO-Ts by quantifying the available functional hydroxyl groups (-OH) on the transducer surface necessary for biosensor development. The best ZnO-T sample was chemically modified and bioconjugated with biotin as  ...[more]

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