The pleiotropic AMPK-CncC signaling pathway regulates the trade-off between detoxification and reproduction.

ABSTRACT: The association of decreased fecundity with insecticide resistance and the negative sublethal effects of insecticides on insect reproduction indicates the typical trade-off between two highly energy-demanding processes, detoxification and reproduction. However, the underlying mechanisms are poorly understood. The energy sensor adenosine monophosphate-activated protein kinase (AMPK) and the transcription factor Cap "n" collar isoform C (CncC) are important regulators of energy metabolism and xenobiotic response, respectively. In this study, using the beetle Tribolium castaneum as a model organism, we found that deltamethrin-induced oxidative stress activated AMPK, which promoted the nuclear translocation of CncC through its phosphorylation. The CncC not only acts as a transcription a

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10013871 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature