A catalytic enantioselective stereodivergent aldol reaction.

ABSTRACT: The aldol reaction is among the most powerful and strategically important carbon-carbon bond-forming transformations in organic chemistry. The importance of the aldol reaction in constructing chiral building blocks for complex small-molecule synthesis has spurred continuous efforts toward the development of direct catalytic variants. The realization of a general catalytic aldol reaction with control over both the relative and absolute configurations of the newly formed stereogenic centers has been a longstanding goal in the field. Here, we report a decarboxylative aldol reaction that provides access to all four possible stereoisomers of the aldol product in one step from identical reactants. The mild reaction can be carried out on a large scale in an open flask, and generates CO₂

SUBMITTER: Rahman MA 

PROVIDER: S-EPMC10017038 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature