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Assessing the prevalence and characteristics of self-reported penicillin allergy in Saudi Arabian population: A nationwide cross-sectional study.


ABSTRACT:

Introduction

Being allergic to penicillin can lead to the overuse of broad-spectrum antibiotics, contributing to the growing problem of multidrug resistance. Knowing the exact allergy history is essential as some circumstances may allow reinitiating penicillin. This study focused on assessing the prevalence and characteristics of self-reported penicillin allergy in the Saudi Arabian population.

Methods

We conducted a nationwide cross-sectional study via an electronic self-administered questionnaire directed toward the Saudi Arabian general adult population. Variables about respondent demographics as well as type and characteristics of the allergy were collected.

Results

One hundred ninety-three out of 2022 participants who completed the survey (9.5%) reported allergy to penicillin, with the most reported reaction being anaphylaxis in 89 participants (46.1%), non-anaphylaxis reported by 69 participants (35.8%). Twenty-two participants (11.4%) were identified as not having a true allergy due to reporting a tolerability issue or a non-penicillin-type agent. About 38% reported that the allergy occurred more than ten years ago.

Conclusion

This is the first study to report the prevalence and characteristics of self-reported penicillin allergy in Saudi Arabia. The data from this study provides valuable information to consider starting in-hospital penicillin de-labeling programs and providing evidence for healthcare providers to consider re-challenging certain qualified patients.

SUBMITTER: Alowais SA 

PROVIDER: S-EPMC10023521 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Assessing the prevalence and characteristics of self-reported penicillin allergy in Saudi Arabian population: A nationwide cross-sectional study.

Alowais Shuroug A SA   Almohareb Sumaya N SN   Bin Saleh Khalid K   Asiri Ibrahim M IM   Badreldin Hisham A HA   Alqazlan Lena L   Albasseet Maram M   Fetyani Lolwa L   Alshehri Lina Ali LA   Almutairi Areej M AM  

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 20221215 2


<h4>Introduction</h4>Being allergic to penicillin can lead to the overuse of broad-spectrum antibiotics, contributing to the growing problem of multidrug resistance. Knowing the exact allergy history is essential as some circumstances may allow reinitiating penicillin. This study focused on assessing the prevalence and characteristics of self-reported penicillin allergy in the Saudi Arabian population.<h4>Methods</h4>We conducted a nationwide cross-sectional study via an electronic self-administ  ...[more]

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