High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight.

ABSTRACT:

Background/objective

As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity.

Methods

Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice.

Results</

SUBMITTER: Korgan AC 

PROVIDER: S-EPMC10023568 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature