Risk Genetic Variants (IL-10) for Osteoporosis in Han Population from Northwest China.

ABSTRACT:

Background

Osteoporosis (OP) is a common metabolic bone disease characterized by loss of bone mass. IL-10 is considered to be a powerful immune and inflammatory suppressor. This study aimed to assess association between genetic loci in IL-10 and susceptibility to OP.

Methods

Association analysis between IL-10 genetic loci and OP risk through SNPStats online software. FPRP analysis (false-positive report probability) verified whether the positive results were noteworthy findings. Linkage disequilibrium (LD) and haplotype analysis were completed by Haploview 4.2 and SNPStats. Multi-factor dimensionality reduction (MDR) was used to assess interaction of SNP-SNP in susceptibility to OP.

Results

Allele "G" of IL-10-rs1554286 (OR = 1.21, p = 0.01

SUBMITTER: Rong K 

PROVIDER: S-EPMC10024466 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature