¹⁸F-Florzolotau PET imaging captures the distribution patterns and regional vulnerability of tau pathology in progressive supranuclear palsy.

ABSTRACT:

Purpose

Human post mortem studies have described the topographical patterns of tau pathology in progressive supranuclear palsy (PSP). Recent advances in tau PET tracers are expected to herald the next era of PSP investigation for early detection of tau pathology in living brains. This study aimed to investigate whether ¹⁸F-Florzolotau PET imaging may capture the distribution patterns and regional vulnerability of tau pathology in PSP, and to devise a novel image-based staging system.

Methods

The study cohort consisted of 148 consecutive patients with PSP who had undergone ¹⁸F-Florzolotau PET imaging. The PSP rating scale (PSPrs) was used to measure disease severity. Similarities and differences of tau deposition among different clinical phenotypes were

SUBMITTER: Liu FT 

PROVIDER: S-EPMC10027831 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature