High endothelial venules in intracranial germinomas: Implications for lymphocytes infiltration.

ABSTRACT:

Purpose

Reactive lymphocytes are substantial components of germinoma, which are believed to be related to the favorable prognosis of this intracranial tumor and better response to immunotherapy. However, the mechanisms managing the recruitment of lymphocytes are poorly understood. High endothelial venules (HEVs) are specialized blood vessels that play key roles in lymphocyte trafficking in Lymph nodes. These vessels are associated with lymphocyte infiltration in chronic inflammatory diseases and various malignant tumors, but their distribution and implications in germinoma are unknown. This study aimed to investigate the distribution and implications of HEVs in intracranial germinomas.

Methods

We investigated the presence and distribution of HEVs in 42 germinomas by immunohi

SUBMITTER: Chen H 

PROVIDER: S-EPMC10028053 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature