Systemic inflammation and subsequent risk of amyotrophic lateral sclerosis: prospective cohort study.

ABSTRACT:

Importance

While systemic inflammation has been implicated in the aetiology of selected neurodegenerative disorders, its role in the development of amyotrophic lateral sclerosis (ALS) is untested.

Objective

To quantify the relationship of C-reactive protein (CRP), an acute-phase reactant and marker of systemic inflammation, with ALS occurrence.

Design setting participants

UK Biobank, a prospective cohort study of 502,649 participants who were aged 37 to 73 years when examined at research centres between 2006 and 2010.

Exposure

Venous blood was collected at baseline in the full cohort and assayed for CRP. Repeat measurement was made 3-7 years later in a representative subgroup (N=14,514) enabling correction for regression dilution.

Main outcomes and measures<

SUBMITTER: Batty GD 

PROVIDER: S-EPMC10029031 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature