Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

ABSTRACT:

Objective

Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed mental and physical health problems, prior pharmacological treatments, and aggregate genetic factors has potential to inform risk stratification and mitigation strategies.

Methods

In this study of 3,942 SCZ and 5,414 BPI patients receiving VA care, self-reported SB and ideation were assessed using the Columbia Suicide Severity Rating Scale (C-SSRS). These cross-sectional data were integrated with electronic health records (EHR), and compared by lifetime diagnoses, treatment histories, follow-up screenings, and mortality data. Polygenic scores (PGS) for trait

SUBMITTER: Bigdeli TB 

PROVIDER: S-EPMC10029042 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature