Thrombophilia and outcomes of venous thromboembolism in older patients.

ABSTRACT:

Background

Limited data exist on thrombophilic risk factors and clinical outcomes in the elderly with venous thromboembolism (VTE).

Objectives

To describe the prevalence of laboratory thrombophilic risk factors and their association with VTE recurrence or death in a cohort of elderly people with VTE.

Methods

In 240 patients aged ≥65 years with acute VTE without active cancer or an indication for extended anticoagulation, we performed laboratory thrombophilia testing 1 year after the index VTE. Recurrence or death was assessed during the 2-year follow-up.

Results

A total of 78% of patients had ≥1 laboratory thrombophilic risk factor(s). Elevated levels of von Willebrand factor, homocysteine, coagulant activity of factor VIII (FVIII:C), fibrinogen, FIX:C, and low

SUBMITTER: Mean M 

PROVIDER: S-EPMC10031374 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature