Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits.

ABSTRACT:

Background

Perivascular spaces on brain magnetic resonance imaging (MRI) may indicate poor fluid drainage in the brain and have been associated with numerous neurological conditions. Cerebrovascular reactivity (CVR) is a marker of cerebrovascular function and represents the ability of cerebral blood vessels to regulate cerebral blood flow in response to vasodilatory or vasoconstrictive stimuli. We aimed to examine whether pathological widening of the perivascular space in older adults may be associated with deficits in CVR.

Methods

Independently living older adults free of dementia or clinical stroke were recruited from the community and underwent brain MRI. Pseudo-continuous arterial spin labeling MRI quantified whole brain cerebral perfusion at rest and during CVR to hyper

SUBMITTER: Kapoor A 

PROVIDER: S-EPMC10033456 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature