Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study.

ABSTRACT:

Introduction

We sought to characterize cognitive profiles associated with enlarged perivascular spaces (EPVS) among Chinese older adults.

Methods

This population-based study included 1191 dementia-free participants (age ≥60 years) in the MIND-China MRI Substudy (2018-2020). We visually evaluated EPVS in basal ganglia (BG) and centrum semiovale (CSO), white matter hyperintensities (WMHs), lacunes, cerebral microbleeds (CMBs), and cortical superficial siderosis. We used a neuropsychological test battery to assess cognitive function. Data were analyzed using general linear models.

Results

Greater BG-EPVS load was associated with lower z-scores in memory, verbal fluency, and global cognition (p < 0.05); these associations became non-significant when controll

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11264110 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature