Nlrp12 deficiency alters gut microbiota and ameliorates Fas^lpr -mediated systemic autoimmunity in male mice.

ABSTRACT: NLRP12 has dual roles in shaping inflammation. We hypothesized that NLRP12 would modulate myeloid cells and T cell function to control systemic autoimmunity. Contrary to our hypothesis, the deficiency of Nlrp12 in autoimmune-prone B6.Fas^lpr/lpr mice ameliorated autoimmunity in males but not females. Nlrp12 deficiency dampened B cell terminal differentiation, germinal center reaction, and survival of autoreactive B cells leading to decreased production of autoantibodies and reduced renal deposition of IgG and complement C3. In parallel, Nlrp12 deficiency reduced the expansion of potentially pathogenic T cells, including double-negative T cells and T follicular helper cells. Furthermore, reduced pro-inflammatory innate immunity was observed, where the g

SUBMITTER: Abdelhamid L 

PROVIDER: S-EPMC10036793 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature