Early recovery of cognition and brain plasticity after surgery in children with low-grade frontal lobe tumors.

ABSTRACT:

Background

Low-grade frontal lobe tumors (LGFLT) can be cured through total resection, but surgical trauma could impair higher-order cognitive function. We aim to characterize the short-term natural cognitive recovery and brain plasticity in surgically-treated pediatric patients with LGFLT.

Methods

Ten pediatric patients with LGFLT were enrolled. Their cognitive function was assessed before the surgery (S0), in the first month post-surgery (S1), and 3-6 months post-surgery (S2), using the CNS Vital Signs battery. DTI and rs-fMRI were performed during the same time periods. Changes of cognition and image metrics between S1>S0 and S2>S1 were analyzed.

Results

The Motor Speed (MotSp) and Reaction Time (RT) scores significantly decreased in S1 and recovered in S2. Rs-fMRI

SUBMITTER: Zheng W 

PROVIDER: S-EPMC10036824 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature